When you think about top vacation destinations in the US, Missouri might not come to mind immediately. But the “Cave State” is named for its 7,000+ natural caves, and guess what? That appeal to nature is reflected in many of the area’s vacation spots.
Whether it’s natural beauty, history, or architectural bliss that you seek, Missouri has an impressive array of options for your next vacation. We’ll cover a roundup of the most unique places to stay in Missouri, including modern treehouses, boutique hotels, and farm-themed accommodations.
So, if you’re ready to make your Missouri getaway one of the best, don’t miss these 7 super unique places to stay.
1. Rustic Cabin Retreat

- Pineville, Missouri
- Best for nature, privacy, and romantic getaways
Aching for a romantic retreat away from the city’s hustle and bustle? Pineville, Missouri, is a small town of under 1,000 people, perfect to escape city stresses.
This rustic cabin retreat is secluded and nestled within a wooded forest and features homey comforts like a warm wood stove, spacious claw-footed tub, and a cozy loft-style bedroom with views of gorgeous sunrises each morning.
Our favorite part? The on-site chicken coop, where you can collect fresh eggs for breakfast each day. The property spans two acres and is a short, ten-minute drive from the Back 40 hiking trails. You’re also not far from Bentonville, Arkansas, if you want to venture off to a restaurant or bar.
Otherwise, enjoy the BBQ grill and on-site firepit for wholesome evenings under the stars!
Book your getaway to the Rustic Cabin Retreat in Pineville.
2. Chayton Trail Cabin

- Rolla, Missouri
- Best for natural light and cozy retreats
If you’re a fan of unique architecture and natural light, this Chayon Trail Cabin is a must-visit. It’s secluded and surrounded by tall tranquil trees. Still, it’s a convenient drive from the Lane Springs Recreation Area and Mark Twain National Forest, perfect for your daytime adventuring.
The cabin itself is thoughtfully constructed into a triangular shape, with the bedroom one floor up at the tip of the triangle. Natural light flows through every room through its wide-panelled glass, gifting guests with stunning views at every hour of the day.
Book your getaway to the Chayton Trail Cabin in Rolla.
3. Lakefront Oasis

- Eldon, Missouri
- Best for water activities
Itching for a relaxing day on the water? This lakefront oasis is the perfect fit, sitting right on its own private cover in Eldon, Missouri. Access the water from multiple decks, and make use of the property’s many water toys, including:
- Paddleboards
- Pedalboats
- Kayaks
There’s also a private dock where you can bring your own fishing boat or tritoon to have your own boat adventure. Inside, you’ll find ample bedrooms equipped with mounted TVs to relax on a day off from the adventures.
Eldon is also home to the natural wonder of the Stark Caverns, where you can check out impressive rock formations, Native American artifacts, and America’s only escape room located within a cave!
Book your getaway to the Lakefront Oasis in Eldon.
4. Garth Woodside Mansion

- Hannibal, Missouri
- Best for history buffs
Anyone with a taste for history or gothic architecture will love a stay at the Garth Woodside Mansion. With roots from the 19th century, this unique boutique hotel has roots in historic American industry, including literature and tobacco. The original owners were descendants of the state’s most famous resident: Mark Twain, aka Samuel Clemens.
The mansion has a number of historically adorned lodging options, including old-fashioned elements like canopy beds, floral wallpaper, Carrara marble fireplaces, velvet textiles, and more. Modern amenities include feather beds, free wi-fi, and a wide array of delectable breakfast options.
Our favorite suite has to be the Dowager House Cottage, nestled in the woods outside the main mansion. It features a spiralled staircase, forest views, and a stone shower with ample privacy for a romantic holiday.
Book your stay to the Garth Woodside Mansion in Hannibal.
5. Postcard Cabins – Ozark Highlands

- Kansas City, Missouri
- Best for glamping and socializing, and pet-friendly stays
Postcard Cabins has a number of communities of glamping cabins across the US, including Texas, and two in Missouri. But our favorite is in Kansas City.
This community of log cabins features 45 suites within a wooded area, placing you with neighbors to socialize with on your trip. Or, you could enjoy the privacy of your cabin and outdoor area, including your very own picnic table and chairs and fire pit.
Rustic and modern merge in this Missouri vacation stay, as you can enjoy air conditioning and a wood stove, alongside scenic views of hardwood tree forests and the Ozark Mountains.
Book your stay to the Ozark Highlands near Kansas City.
6. Huzzah Springs

- Crawford County, Missouri
- Best for big groups
Located in Missouri’s scenic Crawford County, this large accommodation stands out for its relaxing barrel sauna, abundant bedrooms and capacity, high ceilings, and rustic, wooden accents throughout the property. Other modern amenities include a games room and a year-round hot tub.
This is a top-rated stay in the area, as the hosts are hospitable and helpful. They even help coordinate floats, fishing trips, or adventure sports along the nearby river with nearby rental companies. You’re also a short drive from the infamous Huzzah Valley. There, you can enjoy plenty of outdoor activities like horseback riding and kayaking.
Book your stay to Huzzah Springs in Crawford County.
7. Lakefront Condo
- Osage Beach, Missouri
- Best for outdoor pool and lakeside views
This two-bedroom condo spans over 1,000 square feet, and comes with all the amenities you need for a cozy night in. Fry up some steaks on the on-site BBQ grill, warm up by the fireplace, and cook a full-course meal in its fully equipped kitchenette. You’re close to the Ozarks’ lake, but you can also enjoy a swim at the property’s outdoor pool, too.
Boating enthusiasts will also enjoy easy access to their boats at this property’s dock slip (only $30 per night).
You’re also a stone’s throw away from the legendary Lake of the Ozarks State Park, where you can enjoy deer sightings, baseball games, biking trails, and plenty of other outdoor activities.
Book your stay to the Lakefront Condo in Osage Beach.
Explore Unique Stays in Missouri & Beyond!
Michelle Kaufman is a top-rated architect who inspired our exploration of unique stays across the US. We’re delighted to share these impressive stays in Missouri and hope you book one for your next vacation.
And if you’re still on the hunt for more incredible vacation options across the country? We’ve got you covered over on our blog.